Lee Hendrie is suspended after being sent off against Reading in midweek while central defender Ian Evatt is also banned having picked up the requisite number of yellow cards.
"This is what happens at this stage of the season," Grayson told the Blackpool Gazette.
"You often lose players through suspension. But that's why we've got a decent squad.
"It's up to those players who come in now to take their opportunity."