Playing teams from the same division in the early stages of a cup competition can usually be something of an anti-climax but both the Reds and the Lions have reason to give the game everything they've got.
For Championship leaders Forest it is a chance to see once again the squad depth at Billy Davies' disposal as the Scot is likely to make a host of changes from Sunday's hard-earned draw at Watford.
Millwall, meanwhile, earned a first point of the league season from their visit to Sheffield Wednesday and will want to build some momentum under new manager Steve Lomas.
"On the positive side we're not getting broken down as a defensive unit," defender Alan Dunne told the official Millwall FC website following the 2-2 draw at Hillsborough.
"The goals we're conceding are just individual errors which we can cut out."