The televised clash between the league's bottom club and Nottingham Forest also marks the start of Devon and Cornwall's bid to host World Cup 2018 fixtures.
To that end, a number of tickets have been made available on a reduced and even free basis.
Argyle director Keith Todd told the Plymouth Herald: "The Westcountry bid is a people's bid, and this demonstrates perfectly the enthusiasm that the people of the region have for top-flight football."