The last time these two sides met at the City Ground was on November 25, 2000 when Forest won 3-1 thanks to goals from Bart-Williams, Foy and Scimeca.
A repeat of that scoreline today is generally around 14/1.
In-form Jack Lester is 5/1 to score the first goal while Tranmere's top scorer this season, Chris Greenacre (6 goals so far) is a 6/1 chance.